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. 2019 Feb;189(2):272–282. doi: 10.1016/j.ajpath.2018.10.009

Figure 3.

Figure 3

Disruption of PPARα in hepatocytes results in decreased cell cycle gene expression after PHx. A–D: Real-time PCR analysis of cell cycle–related genes Ccna2, Ccnd1, Ccne1, and Pcna mRNA levels in PparaΔHep and Pparafl/fl mice at different time points after PHx. E and F: Western blot analysis of CYCD1 and proliferating cell nuclear antigen (PCNA) protein expression in PparaΔHep mice and Pparafl/fl mice at 0, 3, 6, 12, 24, and 32 hours after PHx. Data are expressed as means ± SD (A–D). n = 5 (A–D). ∗P < 0.05, ∗∗P < 0.01, and ∗∗∗P < 0.001 versus Pparafl/fl. ACTB, β-actin.