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. 2019 Feb;189(2):272–282. doi: 10.1016/j.ajpath.2018.10.009

Figure 5.

Figure 5

Microarray analyses for hepatic gene profiles from hepatocyte PPARα-deficient mice at 12 hours after PHx. A: Up-regulated gene pathways in PparaΔHep mice compared with control mice at 12 hours after PHx. B: Down-regulated gene pathways in PparaΔHep mice compared with Pparafl/fl mice at 12 hours after PHx, as determined by microarray analysis. C: Quantification of Cyp4a10, Cyp4a14, Cpt2, Ehhadh, G6pc, Hmgcs2, Txnip, and Vnn1 mRNAs in PparaΔHep and Pparafl/fl mice. Data are expressed as means ± SD (C). n = 4 (A–C). ∗P < 0.05, ∗∗P < 0.01 versus Pparafl/fl. AMPK, adenosine 5’-monophosphate-activated protein kinase; TCA, tricarboxylic acid cycle.