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. 2019 Jun 4;10:1274. doi: 10.3389/fimmu.2019.01274

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Copyright © 2019 Wu, Li, Wang and Xiao.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Exosomes induce the strongest activation in low-affinity CTLs. Naive OT-I cells were labeled with CFSE and stimulated with peptide with or without Exo for 2 days. (A,D) Representative dot plots and gating for granzyme B (GZB) (A) and CD25 (D) expression. (B,E) Representative data on the production of GZB (B) or CD25 (E) from a set of peptides with altered affinities. (C,F) Pooled data from multiple experiments on the production of GZB (C) and the expression of CD25 (F). Statistics were based on Student's t-test. Data in (A,B,D,E) are representatives of at least 5 experiments.