FIGURE 1.

Reconstructed vitamin/cofactor biosynthesis and salvage pathways in HGM genomes. Eight B-vitamins, and queuine (Q) are shown in red boxes. Alternative and universal biosynthetic pathways are marked in blue text and highlighted in colored blocks. Biosynthetic reactions and vitamin/vitamer uptake are depicted by solid black and red dashed lines, respectively. Enzymes are shown by white boxes. The detailed information of enzyme commission (EC) numbers, functional annotations, metabolite abbreviations, and transporter names are provided in Supplementary Figure S1.