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. 2019 Jun 6;9:200. doi: 10.3389/fcimb.2019.00200

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Copyright © 2019 Ripoll, Wallqvist and Chaudhury.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Structural models of DENV envelope used for simulations. Representative structures are shown for smooth (A–C) and rough (D–F) conformations. Epitopes and epitope centers for TS (blue) and CR (white) mAbs are highlighted in (B,C,E,F). Structures were generated with maturation corresponding to a prM content of 20%.