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. 2019 Jun 6;9:200. doi: 10.3389/fcimb.2019.00200

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Copyright © 2019 Ripoll, Wallqvist and Chaudhury.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Simulated Ab binding occupancy, neutralization, and ADE in heterotypic secondary DENV infection using the rough virus conformation. Estimated Ab binding occupancy (A), infectivity (B), and ADE (C) at a range of TS and CR Ab concentrations for highly mature (5% rough conformation), moderately mature (10% rough conformation), and low-maturity (30% rough conformation) DENV virions during heterotypic infection.