Table 1.
DENV-specific mAbs used in simulations.
| mAb | Specificity | Virus | Method | PDB ID | Epitope | References |
|---|---|---|---|---|---|---|
| 2D22 | TS | DENV2 | Cryo-EM | 4UIF, 4UIH, 5A1Z | E dimer | De Alwis et al., 2012; Fibriansah et al., 2015 |
| 2H2 | CR | DENV1-4 | Cryo-EM | 3J42 | prM | Henchal et al., 1982; Wang et al., 2013 |
| 5G22 | CR | DENV1-4 | Shotgun mutagenesis | – | prM | Smith et al., 2012, 2016 |
| EDE2 A11 | CR | DENV1-4, ZIKV | X-ray diffraction | 4UTB, 5LCV | EDE2a | Dejnirattisai et al., 2015; Rouvinski et al., 2015; Barba-Spaeth et al., 2016 |
| E16 | TS | WNV | X-ray diffraction | 3IYW, 1ZTX | E–DIII | Nybakken et al., 2005; Kaufmann et al., 2010 |
a
EDE2 stands for “E dimer-dependent epitope” with sensitivity to disruptions in N-linked glycosylation sites at positions 153 and 155 of the DENV E protein.