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. 2019 Jun 4;10:1238. doi: 10.3389/fimmu.2019.01238

Figure 1.

Figure 1

(A) Typical BP patient who had widespread itchy urticarial and erythematous lesions and tense blisters. (B) The histopathological analysis of lesional skin samples shows subepidermal blisters with numerous eosinophilic infiltrates. (C) Direct IF of a peri-blistering lesion reveals the linear deposition of IgG at the dermo-epidermal junction (arrows). (D) Indirect IF detects circulating IgG autoantibodies directing the dermo-epidermal junction of normal salt-split human skin. The IgG reacts with the roof epidermis of an artificial blister (star). This figure has been previously published in the following paper: Nishie (1). New diagnostic tool for bullous pemphigoid: full-length BP180 ELISA.