Table 1.
Clinical and electrocardiographic characteristics according to severity of aortic stenosis
| Variables | Mild AS | Moderate AS | Severe AS | P-value |
|---|---|---|---|---|
| (n = 125) | (n = 233) | (n = 272) | ||
| Clinical | ||||
| Age (years) | 69 (61–77)‡ | 71 (60–77)‡ | 74 (65–80)*,† | <0.001 |
| Male sex (%) | 59.8 | 65.8 | 58.8 | 0.222 |
| Body mass index (kg/m2) | 25.9 ± 4.8† | 26.5 ± 4.2*,‡ | 25.5 ± 3.7† | 0.014 |
| Systolic blood pressure (mmHg) | 148 ± 30 | 145 ± 24 | 144 ± 25 | 0.327 |
| Diastolic blood pressure (mmHg) | 81 ± 14 | 81 ± 12 | 79 ± 13 | 0.237 |
| Hypertension (%) | 53.7 | 49.8 | 52.3 | 0.761 |
| Diabetes mellitus (%) | 17.4 | 15.7 | 20.7 | 0.344 |
| Previous myocardial infarction (%) | 13.6 | 10.0 | 16.3 | 0.114 |
| Dyslipidaemia (%) | 25.7 | 27.5 | 32.7 | 0.305 |
| Familial history (%) | 18.9 | 24.1 | 19.8 | 0.487 |
| NYHA function class (%) | ||||
| III/IV | 9.6 | 16.4 | 31.8 | <0.001 |
| Medication | ||||
| Beta-blockers (%) | 34.6 | 37.0 | 41.1 | 0.438 |
| Calcium channel blockers (%) | 22.0 | 25.9 | 18.6 | 0.155 |
| Renin–angiotensin–aldosterone inhibitor (%) | 37.6 | 42.5 | 40.3 | 0.681 |
| Statins (%) | 30.8 | 40.4 | 44.2 | 0.061 |
| Diuretics (%) | 24.3 | 30.1 | 32.6 | 0.294 |
| Electrocardiography | ||||
| QRS duration (ms) | 99 ± 18†,‡ | 100 ± 17*,‡ | 107 ± 23*,† | <0.001 |
| QRS morphology | <0.001 | |||
| Narrow QRS (%) | 68.8 | 60.8 | 50.7 | |
| Right bundle branch block (%) | 7.3 | 6.2 | 6.3 | |
| Left bundle branch block (%) | 1.0 | 1.9 | 10.8 | |
| Intraventricular conduction delay (%) | 22.9 | 31.1 | 32.2 | |
| Atrial fibrillation (%) | 2.1 | 1.4 | 5.5 | 0.005 |
Values are presented as mean ± standard deviation or median (95% confidence interval).
P-value by ANOVA with Bonferroni-correction (*P < 0.05 vs. mild AS, †P < 0.05 vs. moderate AS, ‡P < 0.05 vs. severe AS).
AS, aortic stenosis; NYHA, New York Heart Association.