Table 5.

Univariable and multivariable Cox proportional hazard models for the total population

Variables	Univariables			Baseline model			Baseline model + mechanical dispersion
	HR	95% CI	P-value	HR	95% CI	P-value	HR	95% CI	P-value
Age (years)	1.06	1.05–1.07	<0.001	1.05	1.04–1.06	<0.001	1.05	1.03–1.06	<0.001
Male sex	0.94	0.75–1.19	0.612
Previous myocardial infarction	2.03	1.52–2.72	<0.001
Diabetes mellitus	1.48	1.12–1.96	0.005
Hypertension	1.19	0.95–1.50	0.131
QRS duration per 10 ms	1.01	1.00–1.02	0.001
AVRa	0.40	0.28–0.56	<0.001	0.42	0.32–0.56	<0.001	0.43	0.32–0.57	<0.001
Aortic valve area (cm2)	0.39	0.29–0.53	<0.001	0.37	0.26–0.53	<0.001	0.42	0.29–0.60	<0.001
LVEF (%)	0.98	0.97–0.99	<0.001	0.98	0.97–0.99	<0.001	0.99	0.98–0.99	0.041
LV mass index (per g/m2)	1.01	1.00–1.01	<0.001
LV stroke volume index (mL/m2)	0.98	0.97–0.99	0.001
LV mechanical dispersion (per 10 ms)	1.20	1.15–1.26	<0.001				1.10	1.04–1.15	<0.001
Model discrimination Statistics		χ2		160.9			181.4b
		−2 Log likelihood		3478			3466b

AVR, aortic valve replacement; EF, ejection fraction; LV, left ventricular.

^aTime-dependent co-variate.

^bDifference with baseline model P < 0.001.