Figure 5.

Fra-1-NA plus c-Fos-NA inhibit breast tumor growth. Mice bearing one tumor received an intratumoral injection of liposomes containing Fra1-NA plus c-Fos-NA. Peptide administered: 5 injections containing 4.5 nmol per injection (dashed line) or vehicle (continuous line) (A,C,E) or 9 nmol per injection (B,D,F) delivered three times a week for 15 days. In (A,C,E), control group: n = 6; treated group: n = 8; in (B,D,F), control group: n = 4; treated group: n = 6. (A,B) Tumor volumes were measured at 3-day intervals during the treatment period. Results are expressed as the percent volume taking the volume of the tumor at 10 days of inoculation as 100%. ^***p < 0.001 (Two-way ANOVA, Bonferroni post-test). (C,D) Tumor growth rates were calculated for each group at the end of the treatment as the slope of the curve obtained by plotting the log₁₀ of the tumor volume in function of the days of treatment. Horizontal bars represent mean (C) or median (D) values according to the distribution of the data (parametric and non-parametric ANOVA, respectively) ^*p < 0.05; ^**p < 0.01. (E,F) Body weight of animals during the treatment period.