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. 2019 Jun 22;21(8):765–776. doi: 10.1016/j.neo.2019.05.007

Figure 1.

Figure 1

SOX4 overexpression is associated with PCa progression and NEPC. SOX4 expression is upregulated during the PCa progression in GSE6919 dataset (A) and GSE35988 dataset (B). SOX4 expression in CRPC and NEPC patients from GSE104768 dataset (C) and Trento/Cornell/Broad 2016 dataset (D). Number of samples (n) and P values (determined by a two-tailed Student’s t test) are as shown. (E) MRNA expression of SOX4 during NE transdifferentiation in the LTL331 system. (F) Western blot tested SOX4 expression in ADT treatment of LNCaP cells. LNCaP cell were continuously cultured in medium with 10% FBS depleted of steroids for 0-3 months.