Table 1.
Clinical details of cohorts studied
| Setting | Total (n) | Entry criteria |
Age (months) |
Sex |
Outcome |
|||||
|---|---|---|---|---|---|---|---|---|---|---|
| n | Median (IQR) | n | Male, n (%) | n | Adverse outcome | Adverse outcome, n (%) | ||||
| FEAST | Kenya, Uganda, and Tanzania | 3170 | Fever and respiratory distress or prostration and impaired perfusion | 3170 | 24 (13–38) | 3170 | 1705 (54) | 3170 | Death | 315 (10) |
| Meningococcal disease | England, Wales, and Northern Ireland, UK | 502 | Neisseria meningitidis culture or PCR positive or purpura fulminans without other cause | 499 | 39 (13–166) | 365 | 192 (53) | 502 | Death | 148 (29) |
| Cerebral malaria | Blantyre, Malawi | 448 | Blantyre coma score ≤2 with Plasmodium falciparum parasitaemia and no other discernible cause of coma | 448 | 45 (29–67) | 448 | 233 (52) | 448 | Death or neurological sequelae | 106 (24) |
| South Africa | Cape Town, South Africa | 61 | Suspected septic shock or severe gastroenteritis and clinician's decision to give fluid resuscitation | 61 | 5 (1–9) | 61 | 36 (59) | 61 | Death or intensive care admission | 20 (33) |
| St Mary's Hospital emergency department | London, UK | 18 863 | Emergency department presentation | 18 862 | 48 (18–110) | 18 861 | 10 467 (55) | 18 717 | Admission to hospital ward or intensive care unit | 1933 (10) |