Table 1.

MicroRNAs (miRNAs) most commonly associated with Huntington’s disease (HD).

MiRNA	Role in HD pathophysiology	Evidence in HD patients	References
MiR-22	Regulates multiple mRNAs involved in the pathogenesis of HD; targets include HDAC4, REST, Rgs2	Down-regulated in the brain	Xiong et al. (2010) and Jovicic et al. (2013)
MiR-132	Negative correlation with p250GAP; targets include p250GAP, MeCP2, REST	Down-regulated in the cortices	Klein et al. (2007) and Chen D. et al. (2018)
MiR-124	Crucial regulator for neuronal differentiation in neurodegeneration; targets include SOX9, PTB1, PGC1	Down-regulated in the brain	Makeyev et al. (2007) and Liu et al. (2015)
MiR-196a	Suppresses mutant HTT expression at the mRNA and protein levels; targets include mutant HTT, ANX1A, BDNF	Up-regulated in the prefrontal cortex	Moumné et al. (2013), Tan L. et al. (2015) and Kunkanjanawan et al. (2016)
MiR-10b-5p	Targets HTT by binding to 3′ UTR sites and reducing expression; targets include mutant HTT, BDNF, CREB1	Up-regulated in the prefrontal cortex	Hoss et al. (2015a,b), Jamwal and Kumar (2015) and Lewis et al. (2005)
MiR-146a	Regulator of inflammation-related mRNA, acts as an inflammatory response repressor in the CNS; targets include mutant HTT, TBP	Up-regulated in the brain	Sonkoly et al. (2008), Sinha et al. (2010) and Laprairie et al. (2019)