TABLE 1.
PMA EC50 values for each virusa
| Strain | EC50 (nM) | 95% confidence interval | P value |
|---|---|---|---|
| WT | 0.3074 | 0.2263 to 0.4174 | |
| M1 | 0.3472 | 0.2658 to 0.4534 | 0.63 |
| M2 | 0.6797 | 0.5824 to 0.7931 | 0.025 |
| ERK | 1.517 | 1.226 to 1.877 | 0.0011 |
The PMA EC50 values for each virus were determined as described in the Fig. 5 legend. Confidence intervals were used to derive a T statistic and a P value for the comparison with the wild type. There were no significant differences in the EC50 values for the M1 mutant, but the EC50 values were higher for both the M2 and ERK mutants.