TABLE 1.

Genes repressed by MtsR with differential regulation in the vaginal tract

Gene	Name	Description	Fold changea	P valueb
spy49_0247	pbp7	d-Alanyl–d-alanine carboxypeptidase	2.4	0.00565
spy49_0339	nrdF.2	Ribonucleotide reductase	432.03	3.60E−27
spy49_0340	nrdI	Ribonucleotide reductase stimulatory protein	1079.15	6.20E−20
spy49_0341	nrdE.2	Ribonucleotide diphosphate reductase	245.77	1.80E−29
spy49_0381	mtsA	Metal ABC transporter, substrate binding	6.23	1.10E−19
spy49_0382	mtsB	Metal ABC transporter, ATP binding	1.83	0.00791
spy49_0383	mtsC	Metal ABC transporter, permease	2.24	0.0007
spy49_0661	hupY	Adhesion and heme receptor	27.26	1.10E−21
spy49_0662	hupZ	Enzyme, heme degradation	37.69	8.40E−17
spy49_1159c	manB	Phosphoglucomutase, phosphomannomutase	13.35	3.20E−19
spy49_1374c	dnaK	Chaperone protein	3.05	0.01803
spy49_1395c	siaH	ECF transporter, A component	2.56	0.00283
spy49_1396c	siaG	ECF transporter, T component	2.7	0.00464
spy49_1397c	siaF	ECF transporter, S component	4.71	2.70E−08
spy49_1398c	siaE	Putative ABC transporter	7.03	4.10E−10
spy49_1400c	siaD	Putative ABC transporter	12.49	6.10E−09
spy49_1401c	siaC	Heme ABC transporter, ATP binding	15.68	4.90E−07
spy49_1402c	siaB	Heme ABC transporter, permease	10.82	1.90E−07
spy49_1403c/ 1404cc	siaA/shp	Heme ABC transporter, substrate binding/streptococcal heme-associated protein	20.58	3.80E−08
spy49 _1405c	shr	Streptococcal hemoprotein receptor	25.46	4.10E−12
spy49_1687c	prsA	Foldase	144.61	7.43E−17

^aFold upregulation in the vaginal tract compared to liquid growth.

^bFalse discovery rate-corrected P value.

^cAnnotation of NZ131 incorrectly lists spy49_1403c (siaA) and spy49_1404c (shp) as a single fused gene product rather than two distinct genes.