Figure 1.

The figure shows Nox4 together with p22phox in the endoplasmatic reticulum. Nox4 produces H₂O₂, which builds a ‘redox cloud’. A microtubule is passing the cloud, which enables transport proteins (e.g. kinesins) to bring target proteins into the redox surrounding. This eventually results in the oxidation of the target protein and its release from the transport protein. The oxidized target protein may then mediate redox signalling, control gene expression or could even be decomposed. The possibility of oxidized transport proteins or tubulin is not shown