Figure 1.

NRP1 is upregulated in NSCLC tissues and cell lines. A and B, Data on NRP1 mRNA expression in lung carcinoma and normal lung tissues from several study groups deposited in the Oncomine database (http://www.oncomine.org). C, Survival analysis of 241 NSCLC patients from the GEPIA database stratified by NRP1 expression. (P = 0.041). D, The effect of the NRP1 expression level on overall survival in 1926 lung cancer patients was analysed, and Kaplan–Meier plots were generated using a Kaplan–Meier plotter (http://www.kmplot.com, Affy ID: 210615_at). E, NRP1 mRNA levels in 55 NSCLC tissues and paired noncancerous lung tissues. F, The level of NRP1 mRNA and protein in human NSCLC cells was measured using qRT‐PCR and western blotting, respectively. N, paired noncancerous lung tissues, T, non‐small cell lung cancer tissues. *P < 0.05; *P < 0.01; ***P < 0.001. [Color figure can be viewed at wileyonlinelibrary.com]