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. 2019 Jun 19;10:1361. doi: 10.3389/fimmu.2019.01361

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Copyright © 2019 Rönnberg, Ghaib, Ceriol, Enoksson, Arock, Säfholm, Ekoff and Nilsson.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Decrease in FcεRI surface expression by IL-33. ROSA cells (A,D), CBMCs (B,E), or HLMCs (C) were repeatedly treated every day for 4 days with 10 ng/ml IL-33, TSLP or a combination of both. In addition, IL-4 was added on day 0 (A,B) or 4 days prior to the addition of IL-33 and TSLP (D,E) to upregulate the FcεRI receptor. IL-4 was not added to HLMCs (C). Surface FcεRIα receptor expression was measured by flow cytometry; representative histograms are shown in (A–C) and quantification of the expression is shown below. The MFI of FcεRI was normalized to that of the isotype control. Data shown were pooled from 3 to 5 independent experiments, n = 6–10.