Table 4.

Accuracy for all readers and observation methods

	Scanner A	Scanner B	Scanner C	Scanner D	Microscope
Observer.1	0.713	0.743	0.685	0.706	0.764
Observer.2	0.700	0.715	0.631	0.648	0.778
Observer.3	0.704	0.738	0.717	0.802	0.806
Observer.4	0.691	0.726	0.699	0.717	0.842
Observer.5	0.698	0.754	0.738	0.785	0.802
Average	0.701	0.735	0.694	0.732	0.798
SE	0.021	0.023	0.028	0.035	0.021
95% CI	(0.659, 0.743)	(0.689, 0.780)	(0.636, 0.752)	(0.653, 0.810)	(0.754, 0.842)
p-value	0.001*	0.009*	0.001*	0.062

Accuracy refers to the average of sensitivity and specificity. SE, standard error; CI, confidence interval. The p-value corresponds to a two-sided hypothesis test comparing reader-averaged accuracy with each scanner viewing mode to the accuracy of the microscope. The p-values of the four hypotheses are compared following the sequentially rejective Bonferroni test with alpha = 0.05 [33]. Statistical significance is indicated with an asterisk *. All analyses account for the correlations and variability from the readers reading the same ROIs, and the correlations arising from MFs contained within the same slides