Table 1.
Known adaptive missense polymorphisms with their eForb status using both the Original and Modified EP methods. Table modified from Patel et al. [3]
| Protein | SNP Identifier | Phenotype | Is eForb? | |
|---|---|---|---|---|
| Original EP | Modified EP | |||
| ALMS1 | rs10193972 | insulin resistance | yes | yes |
| rs2056486 | insulin resistance | yes | yes | |
| rs3813227 | insulin resistance | yes | yes | |
| rs6546837 | insulin resistance | yes | yes | |
| rs6546838 | insulin resistance | yes | yes | |
| rs6546839 | insulin resistance | yes | yes | |
| rs6724782 | insulin resistance | yes | yes | |
| APOL1 | rs73885319 | Trypanosoma resistance | no | yes |
| DARC | rs12075 | malaria resistance | yes | yes |
| EDAR | rs3827760 | eccrine glands | yes | yes |
| G6PD | rs1050828 | malaria resistance | yes | yes |
| rs1050829 | malaria resistance | yes | yes | |
| HBB | rs334 | malaria resistance | yes | yes |
| MC1R | rs1805007 | skin pigmentation | yes | yes |
| rs1805008 | skin pigmentation | yes | yes | |
| rs885479 | skin pigmentation | yes | yes | |
| SLC24A5 | rs1426654 | skin pigmentation | yes | yes |
| SLC45A2 | rs16891982 | skin pigmentation | yes | yes |
| TLR4 | rs4986790 | immune response | yes | yes |
| rs4986791 | pathogen recognition | yes | yes | |
| TLR5 | rs5744174 | immune response | no | no |
| TRPV6 | rs4987657 | dietary calcium absorption | yes | yes |
| rs4987667 | dietary calcium absorption | yes | yes | |
| rs4987682 | dietary calcium absorption | yes | yes | |