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. 2019 Jun 25;19:627. doi: 10.1186/s12885-019-5819-6

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — miR-221-5p is downregulated during PCa progression in patient samples. a Analysis of GSE21036 dataset [45] for miR-221-5p expression in PCa tissue compared to adjacent normal tissue. Fold change (FC = 0.83) to normal was calculated and data analysed by t-test. b Expression of miR-221-5p in 14 metastatic PCa samples was compared to miR-221-5p expression in 99 primary PCa tissue in GSE21036 dataset. Fold change (FC = 0.66) was calculated and data analysed by t-test. c Data of GSE21036 was grouped according to the indicated Gleason score (GS) and miR-221-5p expression analysed. Adjusted p-value was calculated by one-way ANOVA. d miR-221-5p expression was analysed in samples grouped for pathological stage (T). Data of GSE21036 was analysed by one-way ANOVA