Table 3. Association of Phase 3 Framingham Risk Scores (FRS) With Cerebral Blood Flow.
| Model | Lobe CBF | |||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Frontal | Temporal | Parietal | Occipital | |||||||||||||
| R2, % | P Value for Model | B (SE) | P Value for FRS | R2, % | P Value for Model | B (SE) | P Value for FRS | R2, % | P Value for Model | B (SE) | P Value for FRS | R2, % | P Value for Model | B (SE) | P Value for FRS | |
| Model 1a | 5.6 | .01 | −5.118 (1.968) | .01b | 8.5 | .001 | −5.063 (1.552) | .001c | 9.8 | .001 | −8.060 (2.285) | .001c | 17.5 | <.001 | −12.034 (2.448) | <.001c |
| Model 2d | 12.0 | .12 | −7.924 (3.188) | .02b | 21.6 | .002c | −7.198 (2.411) | .004c | 19.1 | .006 | −11.633 (3.634) | .002c | 26.7 | <.001 | −16.846 (3.872) | <.001c |
Abbreviation: CBF, cerebral blood flow.
a
Model 1 examined the association of log–Framingham Risk Scores at phase 3 with CBF to the frontal, temporal, parietal, and occipital lobes.
b
Associations significant at uncorrected P < .05.
c
Associations statistically significant at Bonferroni-corrected P < .0125.
d
Model 2 included additional covariates: age, sex, education, cognitive status, socioeconomic status, arterial transit time, statin medication use, and units per week of alcohol consumed.