Table 2. Clinical Outcomes in the Matched and Entire Cohort.
| Outcome | Propensity Score–Matched Cohort | Entire Cohort | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| No. (%)a | HR (95% CI) | P Value | No. (%)a | HR (95% CI) | P Value | Adjusted HR (95% CI)b | P Value | |||
| MRA Use (n = 1034) | No MRA Use (n = 1034) | MRA Use (n = 1678) | No MRA Use (n = 2039) | |||||||
| Composite of all-cause death or HF hospitalization | 287 (28.4) | 344 (33.9) | 0.81 (0.70-0.93) | .003 | 503 (30.6) | 739 (36.8) | 0.79 (0.71-0.88) | <.001 | 0.81 (0.71-0.92) | .001 |
| HF hospitalization | 179 (18.7) | 239 (24.8) | 0.70 (0.60-0.86) | <.001 | 335 (21.5) | 494 (26.2) | 0.77 (0.68-0.88) | <.001 | 0.74 (0.63-0.87) | <.001 |
| All-cause death | 157 (15.6) | 159 (15.8) | 0.98 (0.82-1.18) | .85 | 257 (15.7) | 367 (18.4) | 0.83 (0.72-0.95) | .007 | 0.93 (0.78-1.11) | .42 |
| Cardiovascular death | 96 (9.8) | 93 (9.4) | 1.07 (0.84-1.36) | .59 | 155 (9.8) | 217 (11.3) | 0.88 (0.74-1.05) | .16 | 1.03 (0.82-1.29) | .80 |
| Sudden death | 23 (2.5) | 18 (1.9) | 1.59 (0.93-2.78) | .09 | 33 (2.2) | 43 (2.3) | 1.09 (0.73-1.61) | .68 | 1.51 (0.92-2.45) | .10 |
| Any hospitalization | 344 (35.3) | 375 (38.2) | 0.88 (0.77-1.01) | .07 | 580 (36.6) | 779 (40.8) | 0.85 (0.77-0.94) | .002 | 0.84 (0.74-0.96) | .007 |
Abbreviations: HF, heart failure; HR, hazard ratio; MRA, mineralocorticoid receptor antagonist.
a
Number of patients with at least 1 event reported as cumulative 1-year incidence, counted through the entire follow-up period.
b
Adjusted for the clinically relevant variables described in Table 1.