Figure 4.

LS mean (95% CI)^† percentage change from baseline to weeks 52 and 104 in BMD as measured by DXA at (A) the lumbar spine, (B) femoral neck, (C) total hip and (D) distal forearm. Abbreviations: BMD, bone mineral density; CI, confidence interval; LS, least squares. ^† Based on longitudinal data analysis model with fixed effects for treatment, time, prior antihyperglycaemic medication (metformin monotherapy or metformin and another antihyperglycaemic agent), baseline estimated glomerular filtration rate (continuous), menopausal status (men, premenopausal women, women who are perimenopausal or <3 years postmenopausal, women who are ≥3 years postmenopausal) and the interaction of time by treatment