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. 2019 Jun 21;12:4927–4936. doi: 10.2147/OTT.S205582

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© 2019 Yuan et al.

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Inhibition of miR-373 suppressed tumor growth in a mouse xenograft model. (A) SK-N-BE(2) cells infected with antimiR-373 or negative control lentivirus were implanted subcutaneously into NOG mice. The volumes of xenograft tumors were calculated every week. (B) Representative images of xenograft tumors. (C) The average weight of xenograft tumors. (D) Immunohistochemistry were performed to measure the protein levels of Ki67 in xenograft tumors. Tumor levels of miR-373 and SRCIN1 were measured by qRT-PCR (E) and Western blotting (F), respectively. The results are expressed as mean ± SD (n=3).**p<0.01.

Abbreviations: qRT-PCR, quantitative real-time PCR; SRCIN1, SRC kinase signaling inhibitor 1; SD, standard deviation.