Table 1.
The top five Gene Ontology of genes in each module
| Module | GO term | Gene count | Percentage | P value |
|---|---|---|---|---|
| Black module | GO:0006641—triglyceride metabolic process | 4 | 0.016838 | 0.003504 |
| GO:0034447—very low‐density lipoprotein particle clearance | 2 | 0.008419 | 0.026035 | |
| GO:0005977—glycogen metabolic process | 3 | 0.012628 | 0.02648 | |
| GO:0004616—phosphogluconate dehydrogenase (decarboxylating) activity | 2 | 0.008419 | 0.026597 | |
| GO:0042593—glucose homeostasis | 4 | 0.016838 | 0.036994 | |
| Blue module | GO:0000045—autophagosome assembly | 8 | 0.008831 | 3.91E−04 |
| GO:0031225—anchored component of membrane | 13 | 0.014351 | 4.15E−04 | |
| GO:0000422—mitophagy | 7 | 0.007727 | 9.98E−04 | |
| GO:0035615—clathrin adaptor activity | 4 | 0.004416 | 0.00366 | |
| GO:0048333—mesodermal cell differentiation | 4 | 0.004416 | 0.005108 | |
| Brown module | GO:0005149—interleukin‐1 receptor binding | 5 | 0.006932 | 2.72E−04 |
| GO:0009822—alkaloid catabolic process | 3 | 0.004159 | 0.002084 | |
| GO:0005694—chromosome | 9 | 0.012478 | 0.006028 | |
| GO:0016339—calcium‐dependent cell‐cell adhesion via plasma membrane cell adhesion molecules | 5 | 0.006932 | 0.006113 | |
| GO:0046688—response to copper ion | 4 | 0.005546 | 0.006717 | |
| Cyan module | GO:0005149—interleukin‐1 receptor binding | 5 | 0.006932 | 2.72E−04 |
| GO:0042127—regulation of cell proliferation | 12 | 0.016638 | 0.010821 | |
| GO:0005109—frizzled binding | 7 | 0.068001 | 7.87E−09 | |
| GO:1990405—protein antigen binding | 4 | 0.038858 | 7.09E−07 | |
| GO:0030246—carbohydrate binding | 9 | 0.08743 | 1.63E−06 | |
| Green module | GO:0004693—cyclin‐dependent protein serine/threonine kinase activity | 7 | 0.013092 | 4.08E−05 |
| GO:0000502—proteasome complex | 6 | 0.011221 | 0.006056 | |
| GO:0005737—cytoplasm | 124 | 0.23191 | 0.006231 | |
| GO:0008565—protein transporter activity | 6 | 0.011221 | 0.012393 | |
| GO:0002544—chronic inflammatory response | 3 | 0.005611 | 0.013021 | |
| Greenyellow module | GO:0019740—nitrogen utilization | 4 | 0.031204 | 1.07E−06 |
| GO:0008519—ammonium transmembrane transporter activity | 4 | 0.031204 | 3.81E−06 | |
| GO:0072488—ammonium transmembrane transport | 4 | 0.031204 | 8.90E−06 | |
| GO:0016485—protein processing | 6 | 0.046806 | 2.50E−05 | |
| GO:0015695—organic cation transport | 4 | 0.031204 | 4.72E−05 | |
| Magenta module | GO:0005525—GTP binding | 9 | 0.046536 | 0.010217 |
| GO:0008236—serine‐type peptidase activity | 4 | 0.020683 | 0.012926 | |
| GO:0043198—dendritic shaft | 3 | 0.015512 | 0.021781 | |
| GO:0050859—negative regulation of B cell receptor signaling pathway | 2 | 0.010341 | 0.028982 | |
| GO:0005911—cell‐cell junction | 5 | 0.025853 | 0.034829 | |
| Midnightblue module | GO:0048208—COPII vesicle coating | 3 | 0.068666 | 0.00369 |
| GO:0097461—ferric iron import into cell | 2 | 0.045777 | 0.007423 | |
| GO:0008823—cupric reductase activity | 2 | 0.045777 | 0.007678 | |
| GO:0052851—ferric‐chelate reductase (NADPH) activity | 2 | 0.045777 | 0.007678 | |
| GO:0031013—troponin I binding | 2 | 0.045777 | 0.009207 | |
| Pink module | GO:0004013—adenosylhomocysteinase activity | 3 | 0.01313 | 1.81E−04 |
| GO:0019510—S‐adenosylhomocysteine catabolic process | 3 | 0.01313 | 1.89E−04 | |
| GO:0033353—S‐adenosylmethionine cycle | 3 | 0.01313 | 3.75E−04 | |
| GO:0033857—diphosphoinositol‐pentakisphosphate kinase activity | 2 | 0.008753 | 0.015578 | |
| GO:0019838—growth factor binding | 3 | 0.01313 | 0.018746 | |
| Purple module | GO:0017134—fibroblast growth factor binding | 3 | 0.016672 | 0.011684 |
| GO:0007155—cell adhesion | 9 | 0.050017 | 0.012356 | |
| GO:0008305—integrin complex | 3 | 0.016672 | 0.013554 | |
| GO:0004871—signal transducer activity | 6 | 0.033344 | 0.015787 | |
| GO:0004888—transmembrane signaling receptor activity | 6 | 0.033344 | 0.01901 | |
| Red module | GO:0019787—ubiquitin‐like protein transferase activity | 3 | 0.006797 | 0.006085 |
| GO:0030141—secretory granule | 6 | 0.013594 | 0.006222 | |
| GO:0016567—protein ubiquitination | 13 | 0.029453 | 0.009057 | |
| GO:0000281—mitotic cytokinesis | 4 | 0.009062 | 0.009449 | |
| GO:0004842—ubiquitin‐protein transferase activity | 12 | 0.027187 | 0.012324 | |
| Salmon module | GO:0032228—regulation of synaptic transmission, GABAergic | 3 | 0.024876 | 8.10E‐04 |
| GO:0003682—chromatin binding | 6 | 0.049751 | 0.017248 | |
| GO:0001841—neural tube formation | 2 | 0.016584 | 0.028236 | |
| GO:0032403—protein complex binding | 4 | 0.033167 | 0.045062 | |
| GO:0004065—arylsulfatase activity | 2 | 0.016584 | 0.045254 | |
| Tan module | GO:0033344—cholesterol efflux | 4 | 0.025066 | 3.04E−04 |
| GO:0000062—fatty‐acyl‐CoA binding | 3 | 0.018799 | 0.009724 | |
| GO:0034736—cholesterol O‐acyltransferase activity | 2 | 0.012533 | 0.009928 | |
| GO:0016567—protein ubiquitination | 7 | 0.043865 | 0.012043 | |
| GO:0034435—cholesterol esterification | 2 | 0.012533 | 0.015817 | |
| Turquoise module | GO:0046943—carboxylic acid transmembrane transporter activity | 22 | 22/1068 | 2.75E−05 |
| GO:0005342—organic acid transmembrane transporter activity | 22 | 22/1068 | 8.51E−05 | |
| GO:0000990—transcription factor activity, core RNA polymerase binding | 5 | 5/1068 | 9.92E−05 | |
| GO:0015171—amino acid transmembrane transporter activity | 15 | 15/1068 | 0.00012 | |
| GO:0008514—organic anion transmembrane transporter activity | 26 | 26/1068 | 0.000126 | |
| Yellow module | GO:0008168—methyltransferase activity | 12 | 0.019774 | 7.26E−06 |
| GO:0032259—methylation | 8 | 0.013183 | 0.001149 | |
| GO:0051006—positive regulation of lipoprotein lipase activity | 4 | 0.006591 | 0.001153 | |
| GO:0008016—regulation of heart contraction | 5 | 0.008239 | 0.004648 | |
| GO:0070469—respiratory chain | 4 | 0.006591 | 0.009315 |
Abbreviation: GO, gene ontology.