Table 2.
The KEGG pathway of genes in each module
| Module | Pathway ID | Name | Gene Count | Percentage | P value |
|---|---|---|---|---|---|
| Black module | hsa00520 | Amino sugar and nucleotide sugar metabolism | 3 | 0.012628 | 0.045186 |
| hsa04390 | Hippo signaling pathway | 4 | 0.016838 | 0.047069 | |
| Blue module | hsa04144 | Endocytosis | 18 | 0.019871 | 0.004138 |
| hsa04721 | Synaptic vesicle cycle | 6 | 0.006624 | 0.006681 | |
| hsa00330 | Arginine and proline metabolism | 5 | 0.00552 | 0.029789 | |
| Brown module | hsa04120 | Ubiquitin mediated proteolysis | 10 | 0.013865 | 0.002843 |
| hsa05140 | Leishmaniasis | 6 | 0.008319 | 0.018629 | |
| hsa05166 | HTLV‐I infection | 11 | 0.015251 | 0.03135 | |
| hsa04380 | Osteoclast differentiation | 7 | 0.009705 | 0.045 | |
| Cyan module | hsa04390 | Hippo signaling pathway | 8 | 0.077715 | 1.23E−05 |
| hsa04916 | Melanogenesis | 7 | 0.068001 | 1.28E−05 | |
| hsa05205 | Proteoglycans in cancer | 8 | 0.077715 | 7.54E−05 | |
| hsa04310 | Wnt signaling pathway | 7 | 0.068001 | 7.95E−05 | |
| hsa04550 | Signaling pathways regulating pluripotency of stem cells | 7 | 0.068001 | 8.61E−05 | |
| Greenyellow module | hsa04910 | Insulin signaling pathway | 3 | 0.023403 | 0.048142 |
| Midnightblue module | hsa05321 | Inflammatory bowel disease (IBD) | 2 | 0.045777 | 0.04432 |
| Pink module | hsa04110 | Cell cycle | 5 | 0.021883 | 0.015659 |
| hsa00270 | Cysteine and methionine metabolism | 3 | 0.01313 | 0.035222 | |
| hsa00071 | Fatty acid degradation | 3 | 0.01313 | 0.046016 | |
| hsa04360 | Axon guidance | 4 | 0.017506 | 0.049474 | |
| hsa05210 | Colorectal cancer | 3 | 0.01313 | 0.05423 | |
| Purple module | hsa04620 | Toll‐like receptor signaling pathway | 4 | 0.02223 | 0.022536 |
| hsa05134 | Legionellosis | 3 | 0.016672 | 0.038277 | |
| hsa04810 | Regulation of actin cytoskeleton | 5 | 0.027787 | 0.041896 | |
| hsa04514 | Cell adhesion molecules (CAMs) | 4 | 0.02223 | 0.048926 | |
| Red module | hsa04668 | TNF signaling pathway | 6 | 0.013594 | 0.034553 |
| hsa05168 | Herpes simplex infection | 8 | 0.018125 | 0.036667 | |
| hsa00600 | Sphingolipid metabolism | 4 | 0.009062 | 0.045715 | |
| hsa04141 | Protein processing in endoplasmic reticulum | 7 | 0.015859 | 0.048733 | |
| hsa04668 | TNF signaling pathway | 6 | 0.013594 | 0.034553 | |
| Salmon module | hsa05034 | Alcoholism | 4 | 0.033167 | 0.015651 |
| hsa04550 | Signaling pathways regulating pluripotency of stem cells | 3 | 0.024876 | 0.036596 | |
| hsa04151 | PI3K‐Akt signaling pathway | 4 | 0.033167 | 0.044344 | |
| hsa05034 | Alcoholism | 4 | 0.033167 | 0.015651 | |
| Tan module | hsa04144 | Endocytosis | 5 | 0.031332 | 0.0332 |
| hsa00100 | Steroid biosynthesis | 2 | 0.012533 | 0.041422 | |
| Turquoise module | hsa05134 | Legionellosis | 9 | 0.005112 | 0.01348 |
| hsa00330 | Arginine and proline metabolism | 8 | 0.004544 | 0.026941 | |
| hsa04512 | ECM‐receptor interaction | 10 | 0.00568 | 0.03171 | |
| hsa05321 | Inflammatory bowel disease (IBD) | 8 | 0.004544 | 0.043367 | |
| hsa03018 | RNA degradation | 9 | 0.005112 | 0.044812 | |
| Yellow module | hsa04622 | RIG‐I‐like receptor signaling pathway | 6 | 0.009887 | 0.010586 |
| hsa04932 | Nonalcoholic fatty liver disease (NAFLD) | 8 | 0.013183 | 0.025204 | |
| hsa05010 | Alzheimer's disease | 8 | 0.013183 | 0.04148 | |
| hsa00190 | Oxidative phosphorylation | 7 | 0.011535 | 0.041518 | |
| hsa05203 | Viral carcinogenesis | 9 | 0.01483 | 0.042105 | |
| hsa05012 | Parkinson's disease | 7 | 0.011535 | 0.05405 |
Abbreviation: Akt, Akt/Protein Kinase B; ECM, extracellular matrix; HTLV, human T‐lymphotropic virus 1; KEGG, Kyoto Encyclopedia of Genes and Genomes; PI3K, phosphatidylinositol 3‐kinase; TNF, tumor necrosis factor.