Table 4.

Mucosal bacteria abundances significantly associated with 5‐aminosalicylic acid (5‐ASA) concentration on different taxonomic levels (regression analysis)

Phylum	Class	Order	Family	Genus	P	B
Proteobacteria	—	—	—	—	1.2 × 10−15	−1.29
Firmicutes	—	—	—	—	2.6 × 10−6	0.48
Bacteroidetes	—	—	—	—	3.1 × 10−4	0.99
Firmicutes	Clostridia	—	—	—	6.1 × 10−21	2.33
Bacteroidetes	Bacteroidia	—	—	—	6.9 × 10−9	2.10
Proteobacteria	Alphaproteobacteria	—	—	—	1.2 × 10−6	−0.87
Firmicutes	Bacilli	—	—	—	1.2 × 10−5	−0.70
Proteobacteria	Betaproteobacteria	—	—	—	5.5 × 10−5	−0.65
Bacteroidetes	Flavobacteriia	—	—	—	4.8 0.10−3	−2.34
Firmicutes	Clostridia	Clostridiales	—	—	2.4 × 10−20	2.62
Bacteroidetes	Bacteroidia	Bacteroidales	—	—	8.2 × 10−10	2.10
Actinobacteria	Actinobacteria	Bifidobacteriales	—	—	1.3 × 10−4	1.94
Firmicutes	Bacilli	Lactobacillales	—	—	1.4 × 10−4	3.37
Proteobacteria	Alphaproteobacteria	Rhizobiales	—	—	9.8 × 10−4	−0.57
Firmicutes	Bacilli	Bacillales	—	—	0.002	−0.49
Firmicutes	Clostridia	Clostridiales	Lachnospiraceae	—	7.8 × 10−13	1.73
Firmicutes	Clostridia	Clostridiales	Ruminococcaceae	—	1.6 × 10−12	2.01
Proteobacteria	Betaproteobacteria	Burkholderiales	Comamonadaceae	—	9.8 × 10−12	−1.27
Firmicutes	Bacilli	Bacilliales	Bacillaceae	—	6.2 × 10−12	−1.32
Proteobacteria	Alphaproteobacteria	Rhizobiales	Brucellaceae	—	2.8 × 10−8	−1.51
Bacteroidetes	Bacteroidia	Bacteroidales	Bacteroidaceae	—	3.9 × 10−5	1.46
Bacteroidetes	Flavobacteriia	Flavobacteriales	Weeksellaceae	—	5.7 × 10−4	−2.95
Bacteroidetes	Bacteroidia	Bacteroidales	Porphyromonadaceae	—	8.2 × 10−4	2.04
Bacteroidetes	Bacteroidia	Bacteroidales	Rikenellaceae	—	0.011	2.38
Proteobacteria	Alphaproteobacteria	Rhizobiales	Methylobacteriaceae	—	0.015	−1.11
Proteobacteria	Betaproteobacteria	Burkholderiales	Alcaligenaceae	—	0.015	2.10
Firmicutes	Clostridia	Clostridiales	Clostridiaceae	—	0.015	1.76
Actinobacteria	Actinobacteria	Actinomycetales	Microbacteriaceae	—	0.029	−0.74
Bacteroidetes	Bacteroidia	Bacteroidales	Prevotellaceae	—	0.031	3.60
Actinobacteria	Actinobacteria	Bifidobacteriales	Bifidobacteriaceae	—	0.031	0.99
Firmicutes	Bacilli	Lactobacillales	Streptococcaceae	—	0.035	1.87
Firmicutes	Clostridia	Clostridiales	Ruminococcaceae	Faecalibacterium	4.8 × 10−16	3.16
Firmicutes	Clostridia	Clostridiales	Lachnospiraceae	Blautia	2.1 × 10−14	2.60
Bacteroidetes	Bacteroidia	Bacteroidales	Bacteroidaceae	Bacteroides	1.8 × 10−10	2.72
Firmicutes	Clostridia	Clostridiales	Lachnospiraceae	Coprococcus	3.6 × 10−10	2.41
Firmicutes	Clostridia	Clostridiales	Lachnospiraceae	Dorea	1.8 × 10−8	3.05
Firmicutes	Clostridia	Clostridiales	Lachnospiraceae	Ruminococcus	6.1 × 10−8	3.97
Firmicutes	Clostridia	Clostridiales	Ruminococcaceae	Oscillospira	6.2 × 10−8	3.94
Firmicutes	Clostridia	Clostridiales	Lachnospiraceae	Roseburia	9.6 × 10−8	3.39
Bacteroidetes	Bacteroidia	Bacteroidales	Porphyromonadaceae	Parabacteroides	1.0 × 10−7	3.40
Actinobacteria	Actinobacteria	Bifidobacteriales	Bifidobacteriaceae	Bifidobacterium	1.9 × 10−5	2.10
Firmicutes	Bacilli	Lactobacillales	Streptococcaceae	Streptococcus	5.5 × 10−5	3.55
Proteobacteria	Betaproteobacteria	Burkholderiales	Alcaligenaceae	Sutterella	1.2 × 10−4	3.36
Firmicutes	Clostridia	Clostridiales	Lachnospiraceae	Lachnospira	1.2 × 10−4	2.02
Firmicutes	Clostridia	Clostridiales	Ruminococcaceae	Ruminococcus	2.1 × 10−4	2.76
Actinobacteria	Coriobacteriia	Coriobacteriales	Coriobacteriaceae	Collinsella	1.2 × 10−3	2.17
Bacteroidetes	Bacteroidia	Bacteroidales	Odoribacteraceae	Odoribacter	9.3 × 10−3	2.48
Bacteroidetes	Bacteroidia	Bacteroidales	Prevotellaceae	Prevotella	0.021	4.51
Firmicutes	Clostridia	Clostridiales	Veillonellaceae	Dialister	0.028	1.40
Bacteroidetes	Bacteroidia	Bacteroidales	Weeksellaceae	Cloacibacterium	0.048	−1.62

Bacteria within each taxonomic level are listed by increasing P‐values. P = adjusted P‐value, B = regression coefficient. Red text = increased abundance (positive association), blue = decreased abundance (negative association).