Table 3.
Total brain injury scores in surfactant deficiency newborn piglets treated with SF administered using INSURE or LISA technique (by nasogastric tube (NT) or by LISAcath®)
| Necrosis | Edema | Inflammation | Hemorrhage | Infarct | |
|---|---|---|---|---|---|
| CORTEX | |||||
| INSURE | 8 (2‐15) | 0 | 0.7 (0‐1) | 0 | 0 |
| LISA‐NT | 9 (4‐14) | 0.2 (0‐1) | 0.6 (0‐1) | 0 | 0 |
| LISAcath | 8 (4‐14)$ | 0.4 (0‐1)* | 0.6 (0‐1) | 0 | 0 |
| INNER | |||||
| INSURE | 7 (2‐14) | 0 | 0.4 (0‐1) | 0 | 0 |
| LISA‐NT | 7 (2‐14) | 0.1 (0‐1) | 0.4 (0‐1) | 0 | 0 |
| LISAcath | 8 (0‐12) | 0.2 (0‐1) | 0.4 (0‐1) | 0 | 0 |
| CB+B | |||||
| INSURE | 9 (3‐16) | 0 | 0 | 0 | 0 |
| LISA‐NT | 7 (3‐16) | 0 | 0 | 0 | 0 |
| LISAcath | 8 (4‐16) | 0 | 0 | 0 | 0 |
Statistical differences were observed between groups using Wilcoxon non‐parametric test; (*)P < 0.05 versus INSURE group; ($)P < 0.05 versus LISA‐NT group. Values are expressed as mean ± range. CB + B: cerebellum + brainsterm.