Table 2.
Univariate and Multivariate LR Models
| Variables | Levels (Unit) | n | Coeff | P Value |
|---|---|---|---|---|
| Univariate LR models | ||||
| 122‐5p/151‐5p | ∆Cq | 56 | 1.098 | 0.0025 |
| 151a‐5p/192‐5p | ∆Cq | 56 | −1.643 | 0.0035 |
| Sex | Male vs. female | 56 | −1.609 | 0.0459 |
| Age | years | 56 | 0.0015 | 0.6731 |
| Extent of hepatic resection | Major vs. minor | 56 | 1.695 | 0.1261 |
| Tumor type | HCC vs. CCC | 56 | 0.223 | 0.8128 |
| CRCLM vs. CCC | −18.180 | 0.9934 | ||
| Steatosis (>10%) | Yes vs. no | 56 | −0.594 | 0.4493 |
| Liver cirrhosis | Yes vs. no | 56 | 0.669 | 0.4638 |
| PDR | % | 56 | 0.000 | 0.9938 |
| R15 | % | 56 | 0.067 | 0.2624 |
| SB | mg/dL | 56 | 0.001 | 0.9981 |
| AP | U/L | 56 | 0.006 | 0.0841 |
| AST | U/L | 56 | 0.017 | 0.0377 |
| ALT | U/L | 56 | 0.015 | 0.0941 |
| GGT | U/L | 56 | 0.004 | 0.0662 |
| Albumin | g/L | 56 | −0.170 | 0.0895 |
| Platelet count | ×103/µL | 56 | 0.003 | 0.6140 |
| PT | % | 56 | −0.016 | 0.3850 |
| Change of platelet count | POD 1 / pre‐OP | 56 | 1.198 | 0.2120 |
| Change of PT | POD 1 / pre‐OP | 56 | 0.421 | 0.8473 |
| Change of albumin | POD 1 / pre‐OP | 50* | −0.955 | 0.8769 |
| Multivariate LR models† | ||||
| Intercept | — | 56 | 6.107 | 0.3693 |
| 122‐5p/151‐5p | ∆Cq | 1.023 | 0.0081 | |
| Sex | Male vs. female | −1.523 | 0.2081 | |
| AP | U/L | −0.019 | 0.2762 | |
| AST | U/L | −0.003 | 0.8796 | |
| ALT | U/L | −0.016 | 0.5406 | |
| GGT | U/L | 0.007 | 0.2979 | |
| Albumin | g/L | −0.211 | 0.1733 | |
| Intercept | — | 56 | 37.646 | 0.0061 |
| 151a‐5p/192‐5p | ∆Cq | 6.622 | 0.0001 | |
| Sex | Male vs. female | −4.140 | 0.0188 | |
| AP | U/L | −0.025 | 0.3829 | |
| AST | U/L | −0.201 | 0.0233 | |
| ALT | U/L | 0.086 | 0.1018 | |
| GGT | U/L | 0.004 | 0.7193 | |
| Albumin | g/L | −1.090 | 0.0022 |
P = the P value from Wald test indicating significant influence in the LR model; n = number of patients included in the model with no missing values in any of the selected parameter.
Of note, albumin measurement on POD 1 was missing in 6 patients.
Only variables with P < 0.1 in the univariate LR model were included (indicated in italics), all VIFs between explanatory variables < 4; P values < 0.05 are indicated in bold.
Abbreviations: ΔCq, delta quantification cycle; AP, alkaline phosphatase; Coeff, coefficient of the respective variable in the LR model; CRCLM, colorectal cancer liver metastases; PDR, plasma disappearance rate; PT, prothrombin time; R15, retention rate at 15 minutes; SB, serum bilirubin; VIF, variance inflation factor.