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. 2019 Feb 19;91(6):1158–1167. doi: 10.1002/jmv.25415

Figure 3.

Figure 3

Effect of an increased CSF β‐EP concentration in the morphine‐primed relapse rats. (A) The protocol for morphine‐primed relapse in the rats. (B) The time schedule of the CPP behavioral test in each group. (C) Cartoon of the CPP behavioral test. (D) Statistical analysis of the CPP scores during the preconditioning phase (C1), conditioning phase (C2), the extinction phase (C3), and reinstatement phase (C4). E: Statistical analysis of the locomotion ability indicated by the number of shuttle times (E1) and the total distance (E2). S, saline; M, morphine 10 mg/kg; m, morphine 2 mg/kg; Priming: morphine priming‐induced reinstatement; Ad‐Null *empty type 5 adenovirus with E1/E3 deletion; Ad‐NEP *adenoviral vector expressing β‐EP. *Compared with the Sham group, P < 0.05; **Compared with the Sham group, P < 0.01; ##Compared with the Ad‐NEP group, P < 0.01. Ad‐NEP, adenovirus vector; β‐EP, β‐endorphin; CPP, conditioned place preference; icv, intracerebroventricular