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. 2019 Apr 19;33(7):8623–8633. doi: 10.1096/fj.201802347RRR

Figure 2.

Figure 2

Anastrazole sensitivity and T metabolism are dependent on the concentration of AdMSCs. A) MCF7-derived ducts cultured with a medium and high concentration of AdMSCs in the presence of 10 nM T were exposed to 5 concentrations of anastrazole for 48 h then evaluated for ER transactivation. B) MCF7-derived ducts cultured with a medium and high concentration of late passage primary human mammary adipose stromal cells derived from women with obesity in the presence of 10 nM T were exposed to 5 concentrations of anastrazole for 48 h then evaluated for ER transactivation. C) Schematic showing MCF7-derived ducts cultured with a low, medium, or high concentration of AdMSCs; the ratio of cancer cells to AdMSCs for the low, medium, and high concentration conditions are 1:2, 2:1, and 4:1, respectively. D) MCF7-derived ducts cultured with different concentrations of AdMSCs were exposed to a vehicle control, E2, or T for 48 h then evaluated for ER transactivation. *P < 0.05 vs. vehicle, ‡P < 0.05 vs. E2.