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. 2019 Apr 16;33(7):8335–8348. doi: 10.1096/fj.201801881RR

Figure 2.

Figure 2

Increased APAP-induced liver damage without altering GSH replenishment process in the absence of NR2E3 in vivo. A) Mice were treated with APAP (300 mg/kg), and serum ALT levels were measured at 0-, 6-, 12-, and 24-h time points (only male WT and Nr2e3−/− KO mice were employed; n = 4–5 per each time point). B) Liver damage was evaluated by H&E staining of liver sections derived from APAP-treated WT and Nr2e3−/− KO mice (0 and 24 h). C) GSH levels were reduced at 6 h and then similarly recovered at 24 h in the livers of WT and Nr2e3−/− KO mice after APAP treatment. D, E) Effects of APAP treatment on protein and mRNA induction levels of glutamate-cysteine ligase catalytic subunit and heme oxygenase 1 were shown in the livers of WT and Nr2e3−/− KO mice. Scale bar, 100 μm. Values are represented as means ± sd. *Significant induction or **repression; P < 0.05.