Skip to main content
. 2019 Apr 16;33(7):8335–8348. doi: 10.1096/fj.201801881RR

Figure 4.

Figure 4

Effects of NR2E3 ablation in vivo on ccl4-induced p53 activation and apoptotic cell death. A) Serum ALT levels at 24 h after ccl4 treatment (0.7 ml/kg, i.p.) (n = 4–5). B) H&E staining images of representative liver sections from ccl4-treated or untreated WT and Nr2e3−/− KO mice. C) TUNEL staining of representative liver sections (0 and 24 h). D) The significantly decreased number of TUNEL-positive cells in Nr2e3−/− KO mice treated with ccl4 is shown. E) Impaired p53 activation was confirmed by immunoblotting in the livers of ccl4-treated Nr2e3−/− KO mice. F) Significantly reduced DINO induction was observed in the livers of ccl4-treated NR2E3−/− KO mice. Scale bars, 100 μm. Black arrows indicate TUNEL-positive cells. Values are represented as means ± sd. *Significant induction or **repression; P < 0.05.