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A model proposed for the role of the NR2E3–Sp1 complex in maintaining active DINO epigenetic status and chromatin accessibility essential for p53 activation and downstream events. NR2E3 that forms active complex with Sp1 transcription factor maintains active DINO chromatin status, whereas NR2E3 loss induced repressive DINO chromatin. The proper induction of DINO in turn stabilizes p53 through RNA–protein interaction, amplifying p53 signaling pathways.
