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. 2019 Mar 27;33(7):7929–7941. doi: 10.1096/fj.201802650RR

Figure 6.

Figure 6

A higher HRE binding motif number is associated with an earlier response to hypoxia and to a specific HIF at the time of its maximum activity. A) Logos of the HIF-1 and HIF-2 HRE binding motifs (HOCOMOCO v.9) used in this analysis. B) Cumulative distribution functions of counts of HREs (HIF-1–specific and HIF-2–specific summed) per gene. Numbers of genes forming each group are given in brackets. C) Cumulative distribution functions of the numbers of HIF-1 and HIF-2 motif instances considered separately. The number of HIF-2 instances was significantly (K-S test, P = 0.00241) higher in the 8-h group than in the 16-h group. D) Cumulative distribution functions of the counts of HIF-1 and HIF-2 instances in the 8-h group. The number of HIF-2 instances was significantly (K-S test, P = 0.04891) higher than that of HIF-1 instances.