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. 2019 Apr 10;33(7):8321–8334. doi: 10.1096/fj.201801794R

Figure 4.

Figure 4

Activation of HIF-1α stimulates expression of proliferation and survival genes for stem cells in MRL/MpJ MDSPCs. A, B) Quantitative gene expression analysis of stem cell survival and proliferation marker genes, including Id2, Igf2, and Tgfb3 (A) and angiogenic marker genes Vegfa and Nos2 (B). C) Levels of HIF-1α and Pax7 24 h after CTX-injured skeletal muscle from WT and MRL/MpJ mice (n = 2). Actin was used as loading control. Densitometry is shown below each panel. D) Quantitative gene expression showing mRNA levels of HIF-1α expression and target genes in skeletal muscle after 5 d post-CTX injury in WT and MRL/MpJ mice. CTX, cardiotoxin. Error bars indicate means ± sem from triplicates (P < 0.05).