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. 2019 Mar 28;33(7):8211–8220. doi: 10.1096/fj.201900015RR

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© The Author(s)

This is an Open Access article distributed under the terms of the Creative Commons Attribution 4.0 International (CC BY 4.0) (http://creativecommons.org/licenses/by/4.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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TC-induced concentration-dependent vasoconstriction in rat aortas is inhibited by OATP substrates, UDCA, and the calcium channel blocker nifedipine. A) Vasoconstriction is induced by phenylephrine and TC (n = 13). B) TC responses were abolished in the presence of 1 μM nifedipine, a calcium channel blocker (n = 3, ***P < 0.005). C) TC constriction is abolished in the presence of UDCA (n = 5, **P < 0.01). D) TC constriction is abolished in the presence of OAT inhibitor BSP (n = 7, ***P < 0.005) and ES (n = 4, ***P < 0.005).