Figure 11.

Statins partially block respiratory chain. A) HepG2 cells were treated with SIM (10 µM) for 6 h; 2-DG (50 mM) was added for 20 min followed by oligo (10 µg/ml) for additional 20 min. Image intensity was pseudocolored according to the reference bar. B) Quantitative analysis of TMRM-relative fluorescence after each drug was compared with Veh. Four to 5 randomly selected fields with 10–20 cells per field were analyzed. A.u., arbitrary units. *^,#P < 0.05 from 3 independent experiments.