Figure 2.

Trigeminal CGRP‐ergic C‐fiber nociceptive neurons can secrete CGRP in the trigeminal ganglion, which can diffuse to satellite cells, evoking the release of NO. NO can diffuse back to the TG neuron, as well as to adjacent non‐CGRP neurons, thereby enhancing their activity. Moreover, CGRP can act directly on adjacent non‐CGRP Aδ sensory neuronal cell bodies that express the CGRP receptor, resulting in their sensitization. Calcitonin gene‐related peptide (CGRP); CGRP receptor (CGRP‐R); nitric oxide (NO); neuronal nitric oxide synthase (nNOS); trigeminal ganglion (TG).