Table 1.
Clinicoradiologic data of patients initially classified as Parkinson's disease and controls at baseline evaluation.
| Clinicoradiologic Data | Parkinson's disease | Controls | P valuea |
|---|---|---|---|
| n | 110 | 74 | – |
| Sex, no. M/F | 73/37 | 49/25 | 1b |
| Probable/possible PD level | 70/40 | – | – |
| Age at examination, y, mean ± standard deviation (range) | 62.9 ± 8.1 (42‐80) | 64.3 ± 8.5 (50‐83) | .40c |
| Age at disease onset, y, mean ± standard deviation (range) | 58.5 ± 8.0 (40‐77) | – | – |
| Disease duration, y, mean ± standard deviation (range) | 4.4 ± 3.9 (1‐24) | – | – |
| Clinical features | |||
| Rest tremor, n (%) | 77 (70.0) | – | – |
| Asymmetric motor symptoms, n (%) | 74 (67.2) | – | – |
| MMSE score, median value (range) | 27 (16‐30) | 28 (24‐30) | .005c |
| UPDRS‐ME score, median value (range) | 21 (8‐44) | – | – |
| H‐Y score, median value (range) | 2 (1.5‐3) | – | – |
| Levodopa responsiveness, n (%)d | 91 (82.7) | – | – |
| Brain MRI measurements, mean ± standard deviation (range) | |||
| P/M | 3.87 ± 0.6 (2.67‐5.31) | 3.60 ± 0.4 (2.81‐4.55) | .01e |
| P/M 2.0 | 0.58 ± 0.2 (0.18‐1.19) | 0.52 ± 0.2 (0.15‐0.99) | 1e |
| MRPI | 9.15 ± 1.4 (6.19‐11.93) | 8.84 ± 1.4 (6.25‐12.12) | 1e |
| MRPI 2.0 | 1.37 ± 0.5 (0.40‐2.71) | 1.27 ± 0.5 (0.43‐2.28) | 1e |
F, female; M, male; H‐Y, Hoehn and Yahr rating scale; P/M, pons/midbrain area ratio; MRPI, Magnetic Resonance Parkinsonism Index.
a
Clinicoradiological comparisons at baseline between all patients with initial diagnosis of Parkinson's disease and controls.
b
Fisher's exact test.
c
Mann–Whitney U test.
d
Number (percentage) of patients who showed a clinical improvement of 30% or greater in comparison with that detected in off state.
e
Mann–Whitney U test with Bonferroni correction.