Table 5.
Associations Between Presence of Telomere Gene Variants and Pretransplant/Posttransplant Change in Laboratory Values
| Laboratory Test | Variant Type | N (% Transplant Patients) | Estimate* | 95% CI | P Value† | |
|---|---|---|---|---|---|---|
| In Model | With ≥1 Variant | |||||
| WBC count | Any | 39 (91) | 31 (72) | ‒0.02 | ‒0.31, 0.39 | 0.91 |
| Exonic missense | 39 (91) | 8 (19) | 0.12 | ‒0.22, 0.61 | 0.52 | |
| Likely deleterious | 39 (91) | 5 (12) | 0.05 | ‒0.29, 0.56 | 0.80 | |
| Any RTEL1 | 39 (91) | 11 (26) | 0.22 | ‒0.11, 0.67 | 0.22 | |
| Exonic missense RTEL1 | 39 (91) | 5 (12) | ‒0.06 | ‒0.40, 0.49 | 0.80 | |
| Likely deleterious RTEL1 | 39 (91) | 3 (7) | ||||
| Absolute neutrophil count | Any | 37 (86) | 30 (70) | 0.13 | ‒0.25, 0.70 | 0.56 |
| Exonic missense | 37 (86) | 8 (19) | 0.25 | ‒0.12, 0.79 | 0.21 | |
| Likely deleterious | 37 (86) | 5 (12) | 0.11 | ‒0.26, 0.66 | 0.61 | |
| Any RTEL1 | 37 (86) | 10 (23) | 0.18 | ‒0.16, 0.65 | 0.32 | |
| Exonic missense RTEL1 | 37 (86) | 5 (12) | 0.08 | ‒0.32, 0.71 | 0.74 | |
| Likely deleterious RTEL1 | 37 (86) | 3 (7) | ||||
| Hemoglobin | Any | 39 (91) | 31 (72) | 0.04 | ‒0.07, 0.17 | 0.44 |
| Exonic missense | 39 (91) | 8 (19) | 0.00 | ‒0.11, 0.13 | 0.96 | |
| Likely deleterious | 39 (91) | 5 (12) | ‒0.05 | ‒0.17, 0.08 | 0.40 | |
| Any RTEL1 | 39 (91) | 11 (26) | ‒0.01 | ‒0.11, 0.10 | 0.89 | |
| Exonic missense RTEL1 | 39 (91) | 5 (12) | ‒0.02 | ‒0.15, 0.14 | 0.82 | |
| Likely deleterious RTEL1 | 39 (91) | 3 (7) | ||||
| Platelets | Any | 38 (88) | 30 (70) | 0.68 | 0.09, 1.57 | 0.02 |
| Exonic missense | 38 (88) | 7 (16) | 0.27 | ‒0.24, 1.12 | 0.34 | |
| Likely deleterious | 38 (88) | 4 (9) | ||||
| Any RTEL1 | 38 (88) | 11 (26) | 0.19 | ‒0.19, 0.75 | 0.37 | |
| Exonic missense RTEL1 | 38 (88) | 5 (12) | ‒0.02 | ‒0.46, 0.80 | 0.95 | |
| Likely deleterious RTEL1 | 38 (88) | 3 (7) | ||||
All models are adjusted for age at sample, ethnicity/race (Hispanic/non‐Hispanic white/other), diagnosis (ETOH/HBV or HCV/other), and sex (female/male). Results from models in which fewer than 5 patients have mutations are not shown.
Differences in pretransplant (baseline) and posttransplant (3 months) laboratory values were measured. The corresponding regression coefficient was exponentiated, and the presented estimate should be interpreted as the percent change in the expected geometric mean of pretransplant/posttransplant difference when at least one mutation is present.
Bolded associations had a P value <0.05, but were not statistically significant after Bonferroni correction for multiple comparisons.