Table 6.
Associations Between Presence of Telomere Variants and Posttransplantation Outcomes
| N (% Transplant Patients) | Postoperative Length Of Stay | |||||
|---|---|---|---|---|---|---|
| Variant Type | In Model | With ≥1 Variant | IRR* | 95% CI | P Value | |
| Any | 42 (98) | 34 (79) | 1.60 | 0.89, 2.79 | 0.10 | |
| Exonic missense | 42 (98) | 8 (19) | 2.16 | 1.31, 3.68 | 0.003 | |
| Likely deleterious | 42 (98) | 5 (12) | 2.05 | 1.17, 3.83 | 0.02 | |
| Any RTEL1 | 42 (98) | 14 (33) | 1.07 | 0.67, 1.71 | 0.79 | |
| Exonic missense RTEL1 | 42 (98) | 5 (12) | 1.51 | 0.77, 3.15 | 0.24 | |
| Likely deleterious RTEL1 | 42 (98) | 3 (7) | — | — | — | |
| N (% Transplant Patients) | Posttransplant Readmissions | |||||
| Variant Type | In Model | With ≥1 Variant | IRR* | 95% CI | P Value‡ | |
| Any | 42 (98) | 34 (79) | 3.15 | 1.22, 8.57 | 0.02 | |
| Exonic missense | 42 (98) | 8 (19) | 2.03 | 0.84, 5.29 | 0.08 | |
| Likely deleterious | 42 (98) | 5 (12) | 1.80 | 0.74, 4.77 | 0.21 | |
| Any RTEL1 | 42 (98) | 14 (33) | 1.56 | 0.78, 3.2 | 0.19 | |
| Exonic missense RTEL1 | 42 (98) | 5 (12) | 1.30 | 0.45, 4.04 | 0.61 | |
| Likely deleterious RTEL1 | 42 (98) | 3 (7) | — | — | — | |
| N (% Transplant Patients) | Posttransplant Mortality | |||||
| Variant Type | In Model | With ≥1 Variant | HR‡ | 95% CI | P Value | |
| Any | 39 (91) | 31 (72) | 1.00 | 0.16, 6.16 | >0.99 | |
| Exonic missense | 39 (91) | 7 (16) | 5.15 | 0.84, 31.44 | 0.08 | |
| Likely deleterious | 39 (91) | 5 (12) | 6.15 | 0.84, 44.89 | 0.07 | |
| Any RTEL1 | 39 (91) | 12 (28) | 0.22 | 0.02, 2.06 | 0.19 | |
| Exonic missense RTEL1 | 39 (91) | 4 (9) | — | — | — | |
| Likely deleterious RTEL1 | 39 (91) | 3 (7) | — | — | — | |
All models are adjusted for age at sample, ethnicity/race (Hispanic/non‐Hispanic white/other), diagnosis (ETOH/HBV or HCV/other), and sex (female/male). Results from a model in which fewer than 5 patients have mutations are not shown.
For post‐operative length of stay, the incidence rate ratio (IRR) represents the ratio of LOS when at least one mutation is present vs. when no mutations are present. IRR >1 suggests a risk factor for longer LOS, IRR <1 is protective. For posttransplant readmissions, IRR represents the ratio of readmissions within a year when at least one mutation is present vs. when no mutations are present. IRR >1 suggests a risk factor for more readmissions, IRR <1 is protective.
The HR represents the ratio of mortality rate when at least one mutation is present versus when no mutations are present. An HR >1 suggests a risk factor for mortality; an HR < 1 is protective.
Note: Bolded associations had a P value <0.05, but only the association between exonic missense variants and postoperative stay remained statistically significant after Bonferroni correction for multiple comparisons.
Abbreviation: HR, hazard ratio.