Table 3.
Comparison of insulin resistance indices, metabolic parameters, and body composition parameters between obese polycystic ovary syndrome and nonobese polycystic ovary syndrome
| Variables (units and normal range) | Mean±SD |
P | |
|---|---|---|---|
| Obese PCOS (BMI ≥25 kg/m2) (n=42) | Nonobese PCOS (BMI <25 kg/m2) (n=39) | ||
| Metabolic parameters | |||
| Glucose fasting (70-100 mg/dL) | 97.8±14.7 | 94.7±17.9 | 0.39 |
| 2 h post 75 g blood glucose (<140 mg/dL) | 121.7±41.3 | 117.9±38.4 | 0.67 |
| HbA1c (<5.7%) | 5.6±0.7 | 5.45±0.9 | 0.53 |
| Total cholesterol (<200 mg %) | 173.6±33.2 | 175.6±33.6 | 0.79 |
| Triglycerides (<150 mg %) | 88±43.3 | 80±31.6 | 0.35 |
| HDL-cholesterol (>60 mg %) | 44.3±8.9 | 50.4±10.8 | 0.009 |
| LDL-cholesterol (<100 mg %) | 109.4±29.9 | 107.8±27.8 | 0.79 |
| Non-HDL cholesterol | 129.3±34.9 | 125.2±34.4 | 0.61 |
| Insulin resistance indices | |||
| Fasting insulin (0-30 µU/ml) | 26.1±44.516.3 (6-290)‡ | 8.58±3.87.8 (2-19.3)‡ | 0.01 |
| HOMA-IR (≥2.5) | 7.2±163.8 (1.1-105.2)‡ | 2.1±1.21.8 (0.4-6.6)‡ | 0.05 |
| QUICKI (>0.33) | 0.31±0.030.3 (0.22-0.38)‡ | 0.35±0.030.3 (0.3-0.5)‡ | 0.001 |
| Body composition parameters | |||
| Total body fat (%) | 42.2±3.8 | 37.9±4.7 | 0.0001 |
| Fat trunk/fat legs (%) | 0.9±0.07 | 0.85±0.12 | 0.008 |
| Estimated VAT volume (cm3) | 450.9±150.6 | 309.6±120.7 | 0.0001 |
| Corrected estimated VAT volume to body weight (cm3/kg) | 6.11±1.91 | 5.74±1.91 | 0.39 |
| Fat mass (g) | 31,701±7254 | 20,424±4603 | 0.0001 |
| Total mass (g) | 74,654±11,945 | 53,854±6585 | 0.0001 |
‡Median (minimum-maximum). PCOS=Polycystic ovary syndrome, BMI=Body mass index, HDL=High-density lipoprotein, LDL=Low-density lipoprotein, HOMA-IR=Homeostatic Model Assessment-Insulin Resistance, QUICKI=Quantitative Insulin Sensitivity Check Index, VAT=Visceral adipose tissue, HbA1c=Glycated hemoglobin, SD=Standard deviation