Figure 7.
CD4+ T cells enhance PCa cell chemotherapy resistance in an in vivo mouse study. Ten male nude mice were injected subcutaneously with 2 × 106 CWR22RV1 cells or 2 × 106 CWR22RV1 cocultured with 2 × 105 HH cells. After 2 weeks, the mice were treated with Docetaxel for three weeks and then killed. A, Gross appearance of the tumor xenografts. B, C, Weights of the xenografts tumor and macroscopic appearance of the xenografts tumor. Data are presented as mean ± SD, n = 5, *P < 0.05 vs control. D, IHC staining for Ki67, CCL5, P‐STAT3, and cleaved PARP in mice tumor tissues. CCL5, C‐C motif chemokine ligand 5; IHC, immunohistochemistry; PCa, prostate cancer; PARP, poly ADP ribose polymerase; STAT3, signal transducer and activator of transcription 3 [Color figure can be viewed at wileyonlinelibrary.com]