Figure 5.

Impact of missing deaths on analyses that use the EHR‐derived data as an external control arm: current mortality sensitivity vs simulated sensitivities compared with gold standard benchmark. For the external control analyses, the experimental arm in all analyses is composed of the gold standard data, and the control arm is composed of the EHR‐derived data only. For simulations 1 and 2, the same approach is taken where the experimental arms are composed of the gold standard data, and the control arms are composed of the EHR‐derived data only (with their respective simulated lower sensitivities). Each analysis is in turn compared with an analysis conducted using the gold standard data only (solid red vertical line in Figure 5 represents the HR using the gold standard with dashed line representing its corresponding 95% CI) [Colour figure can be viewed at wileyonlinelibrary.com]