Table 2.

Description of model parameters.

Parameter	Description
λ x	The rate of recruitment of red blood cells
ω s	Antimalarial treatment efficacy
α s, α r	Parasite strain-specific fitness cost
λ w	Background recruitment rate of immune cells
e g, e m, e y	Hill parameters in G i, M i, and Y i dynamics (i=s, r)
μ x	Per capita natural mortality rate of unparasitized erythrocytes
μ ys	Natural mortality rate of drug-sensitive IRBCs
μ yr	Natural death rate of drug-resistant IRBCs
ζ, η	Rate of antimalarial eradication of merozoites and gametocytes, respectively
μ ms	Death rate of drug-sensitive merozoites
μ mr	Mortality rate of drug-resistant merozoites
μ gs	Per capita mortality rate of drug-sensitive gametocytes
μ gr	Mortality rate of drug-resistant gametocytes
μ w	Natural mortality rate of immune cells (CD8 + T cells)
β	The rate of infection of susceptible RBCs by blood floating merozoites
σ r, σ s	Rate of formation of gametocytes from the infected RBCs
P	Number of merozoites produced per dying infected RBC
h y	Immune cell proliferation rate due to IRBCs
h m	Immune cell proliferation rate due to asexual merozoites
h g	Immune cell proliferation rate due to gametocytes
k y	Phagocytosis rate of IRBCs by immune cell
k m	Phagocytosis rate of merozoites by immune cell
k g	Phagocytosis rate of gametocytes by immune cell
Ψ1	Rate of development of resistance by drug-sensitive merozoites
Ψ2	Rate of development of resistance by drug-sensitive gametocytes
δ r	Accounts for the reduced fitness of the resistant parasite strains
γ	Efficiency of immune effector to inhibit merozoite infection
1/a	Half-saturation constant for Y(t), M(t), and G(t)