Table 2.
Receptors and infection models of hepatitis viruses.
| HAV | HBV | HCV | HEV | |
|---|---|---|---|---|
| Receptor | TIM-1 [48] | NTCP [46] | CD81, SR-BI, OCLN, CLDN1 [49–52] | Unknown |
| Cell model | HAV | HBV | HCV | HEV |
| PHH | +[53] | +[46] | +[54] | +[55] |
| HepG2 | +[53] | +/– | – | +[56] |
| HepG2NTCP | Unknown | +[46] | – | Unknown |
| HepaRG | Unknown | +[44] | – | +[57] |
| Huh7 | Unknown | +/– | +/– | +[56] |
| Huh7NTCP | Unknown | +[46] | +/– | Unknown |
| Huh7.5.1 | Unknown | – | +[58, 59] | Unknown |
| HLCZ01 | Unknown | +[60] | +[60] | Unknown |
| PLC/PRF5 | Unknown | Unknown | Unknown | +[61] |
| A549 | Unknown | – | – | +[61] |
| iPSC-derived HLC | Unknown | +[19, 62–64] | +[17, 65] | +[18, 66, 67] |
| hESC-derived HLC | Unknown | +[19] | +[17, 65] | +[18, 66, 67] |
TIM-1: T-cell immunoglobulin and mucin domain 1; NTCP: sodium taurocholate cotransporting polypeptide; CD81: cluster of differentiation 81; SR-BI: scavenger receptor class B type I; OCLN: occluding; CLDN1: claudin-1; PHH: primary human hepatocyte; iPSC: induced pluripotent stem cell; hESC: human embryonic stem cell; HLC: hepatocyte-like cell. +: permissive; +/-: barely permissive; -: not permissive.