Table 2.
Accuracy of mRNA HPV for detection of Cervical Intraepithelial Neoplasia (CIN) in histopathological, Pooled and discerning by mRNA HPV test. Outcomes: CIN1- vs. CIN2+ and CIN1- vs. CIN3+.
| Test | All mRNA HPV assays pooled |
Aptima % (IC 95%) |
NucliSens EasyQ HPV % (IC 95%) |
OncoTect % (IC 95%) |
PreTect HPV Proofer % (IC 95%) |
Quantivirus % (IC 95%) |
|---|---|---|---|---|---|---|
| CIN1- vs. CIN2+ | ||||||
| Sensitivity | 83.3 (82.9-84.6) | 92.8 (91.9-93.7) | 75.9 (72.7-78.9) | 72.4 (67.5-76.9) | 73.2 (71.5-74.9) | 86.6 (82.4-90.1) |
| Specificity | 65.2 (64.5-65.8) | 60.5 (59.8-61.3) | 61.5 (58.5-64.5) | 79.5 (77.4-81.5) | 79.4 (78.3-80.5) | 38.9 (35.1-42.8) |
| DOR | 10.54 (8.35-13.29) | 12.53 (8.97-17.52) | 5.48 (3.37-8.89) | 13.83 (6.40-29.86) | 13.21 (8.55-20.41) | 4.71 (2.59-8.57) |
| AUC | 0.84 (0.81-0.87) | 0.88 (0.82-0.95) | 0.76 (0.69-0.82) | 0.87 (0.82-0.92) | 0.84 (0.79-0.89) | 0.80 (0.66-0.95) |
| TP | 5,840 | 3,220 | 578 | 267 | 1,992 | 278 |
| FP | 7,910 | 6,177 | 392 | 319 | 1,125 | 390 |
| FN | 1,131 | 248 | 184 | 102 | 728 | 43 |
| TN | 14,793 | 9,470 | 627 | 1,238 | 4,337 | 248 |
| N total | 29,674 | 19,115 | 1,781 | 1,926 | 8,182 | 959 |
|
| ||||||
| CIN1- vs. CIN3+∗ | ||||||
| Sensitivity | 86.1 (84.8-87.3) | 95.6 (94.5-96.5) | 83.5 (73.9-90.7) | 85.2 (77.4-91.1) | 67.6 (64.3-70.7) | 85.1 (78.8-90.1) |
| Specificity | 65.5 (64.8-66.2) | 61.9 (61.1-62.7) | 64.1 (55.3-72.3) | 78.6 (77.6-80.6) | 83.9 (82.2-85.5) | 41.5 (36.9-46.2) |
| DOR | 18.93 (12.44-28.82) | 21.45 (12.40-37.11) | 9.67 (0.931-100.54) | 23.33 (8.07-67.49) | 19.57 (4.36-87.85) | 7.28 (4.11-12.88) |
| AUC | 0.88 (0.84-0.92) | 0.91 (0.84-0.99) | 0.78 (0.56-0.99) | 0.84 (0.78-0.89) | 0.71 (0.67-0.76) | 0.79 (0.68-0.89) |
| TP | 2,494 | 15 | 71 | 98 | 579 | 143 |
| FP | 6,238 | 174 | 98 | 351 | 311 | 261 |
| FN | 403 | 0 | 14 | 17 | 278 | 25 |
| TN | 11,854 | 1,799 | 297 | 1,292 | 1,621 | 185 |
| N total | 20,989 | 1,988 | 480 | 1,758 | 2,789 | 614 |
∗Excluding CIN2 from analysis. CIN: cervical intraepithelial neoplasia; CI: Confidence interval; DOR: diagnostic odds ratio; AUC: area under the curve; TP: true positive; FP: false positive; FN: false negative; TN: true negative.